[PDF] Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics. | Semantic Scholar (2024)

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@article{Nakamura2004OralID, title={Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics.}, author={Koji Nakamura and Robert John Murray and Jeffrey I. Joseph and Nicholas A. Peppas and Mariko Morish*ta and Anthony M. Lowman}, journal={Journal of controlled release : official journal of the Controlled Release Society}, year={2004}, volume={95 3}, pages={ 589-99 }, url={https://api.semanticscholar.org/CorpusID:17899959}}
  • Koji Nakamura, R. Murray, A. Lowman
  • Published in Journal of Controlled Release 24 March 2004
  • Materials Science, Medicine

179 Citations

Highly Influential Citations

4

Background Citations

40

Methods Citations

11

Results Citations

4

Figures and Tables from this paper

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179 Citations

Elucidation of the Mechanism of Enhanced Insulin Uptake and Release from pH Responsive Hydrogels
    Anthony TuescaA. Lowman

    Medicine, Materials Science

  • 2008

Results indicate that hydrogen bonds and ionic interactions between the protein and P(MAA-g-EG) may strongly influence its loading and release behavior in vitro.

  • 2
Complexation hydrogels for oral insulin delivery: effects of polymer dosing on in vivo efficacy.
    Anthony TuescaKoji NakamuraM. Morish*taJ. JosephN. PeppasA. Lowman

    Medicine, Materials Science

    Journal of pharmaceutical sciences

  • 2008

Hydrogels comprised of poly(methacrylic acid) grafted with poly(ethylene glycol) (P(MAA-g-EG)) were characterized and examined for their potential as oral insulin carriers and induced a hypoglycemic effect and an increase in insulin levels, proving that insulin was still biologically active.

  • 29
Salicylic acid-based pH-sensitive hydrogels as potential oral insulin delivery systems
    Bahar DemirdirekK. Uhrich

    Chemistry, Materials Science

    Journal of drug targeting

  • 2015

It is suggested that hydrogels enable pH-dependent protein delivery and can be used for oral insulin and SA delivery to benefit diabetes patients.

  • 17
Oral insulin delivery systems based on complexation polymer hydrogels
    M. Morish*taTakahiro GotoK. TakayamaN. Peppas

    Materials Science, Medicine

  • 2006
  • 29
  • PDF
Complexation hydrogels for oral protein delivery: an in vitro assessment of the insulin transport-enhancing effects following dissolution in simulated digestive fluids
    E. PerakslisAnthony TuescaA. Lowman

    Chemistry, Materials Science

    Journal of biomaterials science. Polymer edition

  • 2007

The insulin-transport enhancing effects of a pH-sensitive poly((methacrylic acid)-grafted-poly(ethylene glycol)) hydrogel system were studied using Caco-2 monolayers as an in vitro model of intestinal transport and enhanced transport with the ILP was observed.

  • 8
Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats.
    M. Morish*taTakahiro GotoKoji NakamuraA. LowmanK. TakayamaN. Peppas

    Medicine

    Journal of controlled release : official journal…

  • 2006
  • 179
  • PDF
Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption.
    M. Morish*taTakahiro Goto A. Lowman

    Materials Science, Medicine

    Journal of controlled release : official journal…

  • 2004
  • 137
  • PDF
Development of PEGDMA: MAA based hydrogel microparticles for oral insulin delivery.
    Amit KumarS. S. LahiriHarpal Singh

    Materials Science, Medicine

    International journal of pharmaceutics

  • 2006
  • 63
Oral insulin delivery using pH-responsive hydrogel and gold nanoparticle hybrid carrier
    C. Leung

    Medicine, Materials Science

  • 2010

The utilization of gold nanoparticles as nanoplugs to reversibly block the surface pores of the collapsed microparticles was investigated and found to be a more efficient carrier in delivering insulin to the small intestine, where absorption to bloodstream takes place.

  • Highly Influenced
  • PDF
pH-responsive hydrogels based on the self-assembly of short polypeptides for controlled release of peptide and protein drugs
    Xue BaoX. SiXiaoya DingLijie DuanChunsheng Xiao

    Materials Science, Medicine

    Journal of Polymer Research

  • 2019

The biocompatible and biodegradable 4a-PEG-PLG hydrogel may serve as a promising platform for pH-responsive drug delivery.

  • 22

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23 References

Oral delivery of insulin using pH-responsive complexation gels.
    A. LowmanM. Morish*taMasako KajitaT. NagaiN. Peppas

    Medicine, Chemistry

    Journal of pharmaceutical sciences

  • 1999

P pH-responsive, poly(methacrylic-g-ethylene glycol) hydrogels are investigated as oral delivery vehicles for insulin to protect the sensitive drug from proteolytic degradation in the stomach and upper portion of the small intestine.

  • 386
  • PDF
Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption.
    M. Morish*taTakahiro Goto A. Lowman

    Materials Science, Medicine

    Journal of controlled release : official journal…

  • 2004
  • 137
  • PDF
Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers.
    M. Morish*taA. LowmanK. TakayamaT. NagaiN. Peppas

    Medicine, Materials Science

    Journal of controlled release : official journal…

  • 2002
  • 164
  • PDF
Analysis of the Complexation/Decomplexation Phenomena in Graft Copolymer Networks
    A. LowmanN. Peppas

    Materials Science, Chemistry

  • 1997

Graft copolymer networks of poly(methacrylic acid-g-ethylene glycol) exhibiting pH-dependent swelling behavior due to the formation of interpolymer complexes were prepared by free radical solution

  • 126
  • PDF
Physicochemical behavior and cytotoxic effects of p(methacrylic acid-g-ethylene glycol) nanospheres for oral delivery of proteins.
    M. Torres-LugoMarcos GarcíaR. RecordN. Peppas

    Chemistry, Materials Science

    Journal of controlled release : official journal…

  • 2002
  • 124
  • PDF
Kinetic modeling of the effect of solvent concentration on primary cyclization during polymerization of multifunctional monomers
    J. ElliottJay W. AnsethC. Bowman

    Materials Science, Chemistry

  • 2001
  • 64
Optimized chemical structure of nanoparticles as carriers for oral delivery of salmon calcitonin.
    S. SakumaN. SuzukiR. SudoK. HiwatariA. KishidaM. Akashi

    Chemistry, Materials Science

    International journal of pharmaceutics

  • 2002
  • 60
Bioadhesive potential of gliadin nanoparticulate systems.
    M. A. ArangoaG. PonchelA. OrecchioniM. RenedoD. DuchěneJ. Irache

    Chemistry, Materials Science

    European journal of pharmaceutical sciences…

  • 2000
  • 111
Oral delivery of insulin from enteric-coated capsules containing sodium salicylate: effect on relative hypoglycemia of diabetic beagle dogs.
    E. HosnyH. I. Al-ShoraM. Elmazar

    Medicine

    International journal of pharmaceutics

  • 2002
  • 65
In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption.
    Y. OnukiM. Morish*ta T. Nagai

    Medicine

    International journal of pharmaceutics

  • 2000
  • 43

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    [PDF] Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics. | Semantic Scholar (2024)

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