Skip to search formSkip to main contentSkip to account menu
DOI:10.1016/J.JCONREL.2003.12.022 - Corpus ID: 17899959
@article{Nakamura2004OralID, title={Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics.}, author={Koji Nakamura and Robert John Murray and Jeffrey I. Joseph and Nicholas A. Peppas and Mariko Morish*ta and Anthony M. Lowman}, journal={Journal of controlled release : official journal of the Controlled Release Society}, year={2004}, volume={95 3}, pages={ 589-99 }, url={https://api.semanticscholar.org/CorpusID:17899959}}
- Koji Nakamura, R. Murray, A. Lowman
- Published in Journal of Controlled Release 24 March 2004
- Materials Science, Medicine
179 Citations
4
40
11
4
Figures and Tables from this paper
- figure 1
- table 1
- figure 2
- figure 3
- figure 4
- figure 5
- figure 6
- figure 7
179 Citations
- Anthony TuescaA. Lowman
- 2008
Medicine, Materials Science
Results indicate that hydrogen bonds and ionic interactions between the protein and P(MAA-g-EG) may strongly influence its loading and release behavior in vitro.
- 2
- Anthony TuescaKoji NakamuraM. Morish*taJ. JosephN. PeppasA. Lowman
- 2008
Medicine, Materials Science
Journal of pharmaceutical sciences
Hydrogels comprised of poly(methacrylic acid) grafted with poly(ethylene glycol) (P(MAA-g-EG)) were characterized and examined for their potential as oral insulin carriers and induced a hypoglycemic effect and an increase in insulin levels, proving that insulin was still biologically active.
- 29
- Bahar DemirdirekK. Uhrich
- 2015
Chemistry, Materials Science
Journal of drug targeting
It is suggested that hydrogels enable pH-dependent protein delivery and can be used for oral insulin and SA delivery to benefit diabetes patients.
- 17
- M. Morish*taTakahiro GotoK. TakayamaN. Peppas
- 2006
Materials Science, Medicine
- 29
- PDF
- E. PerakslisAnthony TuescaA. Lowman
- 2007
Chemistry, Materials Science
Journal of biomaterials science. Polymer edition
The insulin-transport enhancing effects of a pH-sensitive poly((methacrylic acid)-grafted-poly(ethylene glycol)) hydrogel system were studied using Caco-2 monolayers as an in vitro model of intestinal transport and enhanced transport with the ILP was observed.
- 8
- M. Morish*taTakahiro GotoKoji NakamuraA. LowmanK. TakayamaN. Peppas
- 2006
Medicine
Journal of controlled release : official journal…
- 179
- PDF
- M. Morish*taTakahiro Goto A. Lowman
- 2004
Materials Science, Medicine
Journal of controlled release : official journal…
- 137
- PDF
- Amit KumarS. S. LahiriHarpal Singh
- 2006
Materials Science, Medicine
International journal of pharmaceutics
- 63
- C. Leung
- 2010
Medicine, Materials Science
The utilization of gold nanoparticles as nanoplugs to reversibly block the surface pores of the collapsed microparticles was investigated and found to be a more efficient carrier in delivering insulin to the small intestine, where absorption to bloodstream takes place.
- Highly Influenced
- PDF
- Xue BaoX. SiXiaoya DingLijie DuanChunsheng Xiao
- 2019
Materials Science, Medicine
Journal of Polymer Research
The biocompatible and biodegradable 4a-PEG-PLG hydrogel may serve as a promising platform for pH-responsive drug delivery.
- 22
...
...
23 References
- A. LowmanM. Morish*taMasako KajitaT. NagaiN. Peppas
- 1999
Medicine, Chemistry
Journal of pharmaceutical sciences
P pH-responsive, poly(methacrylic-g-ethylene glycol) hydrogels are investigated as oral delivery vehicles for insulin to protect the sensitive drug from proteolytic degradation in the stomach and upper portion of the small intestine.
- 386
- PDF
- M. Morish*taTakahiro Goto A. Lowman
- 2004
Materials Science, Medicine
Journal of controlled release : official journal…
- 137
- PDF
- M. Morish*taA. LowmanK. TakayamaT. NagaiN. Peppas
- 2002
Medicine, Materials Science
Journal of controlled release : official journal…
- 164
- PDF
- A. LowmanN. Peppas
- 1997
Materials Science, Chemistry
Graft copolymer networks of poly(methacrylic acid-g-ethylene glycol) exhibiting pH-dependent swelling behavior due to the formation of interpolymer complexes were prepared by free radical solution…
- 126
- PDF
- M. Torres-LugoMarcos GarcíaR. RecordN. Peppas
- 2002
Chemistry, Materials Science
Journal of controlled release : official journal…
- 124
- PDF
- J. ElliottJay W. AnsethC. Bowman
- 2001
Materials Science, Chemistry
- 64
- S. SakumaN. SuzukiR. SudoK. HiwatariA. KishidaM. Akashi
- 2002
Chemistry, Materials Science
International journal of pharmaceutics
- 60
- M. A. ArangoaG. PonchelA. OrecchioniM. RenedoD. DuchěneJ. Irache
- 2000
Chemistry, Materials Science
European journal of pharmaceutical sciences…
- 111
- E. HosnyH. I. Al-ShoraM. Elmazar
- 2002
Medicine
International journal of pharmaceutics
- 65
- Y. OnukiM. Morish*ta T. Nagai
- 2000
Medicine
International journal of pharmaceutics
- 43
...
...
Related Papers
Showing 1 through 3 of 0 Related Papers